Symbol: Name: ID: |
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) GFS:2310 |
Gene name: | UCP3 |
Chromosome: | 11q13.4 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SLC25A9 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1099787 | Rat Genome Database ID: | RGD:3933 |
HGNC ID: | HGNC:12519 | RefSeq IDs: | NM_003356 |
Entrez Gene ID: | 7352 | Ensembl Gene ID: | ENSG00000175564 |
VEGA IDs: | UniProt ID: | P55916 | |
UCSC ID: | uc001our.2 | OMIM ID: | 602044 |
Pubmed: | PMID9480760 PMID 9196039 | ||
CCDS IDs: | CCDSCCDS8229.1 CCDS CCDS44677.1 |
Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Products for UCP3 gene
Catalog | Product Name | Application | Company |
GFS:E02310 | uncoupling protein 3 (mitochondrial, proton carrier); ELISA kit | ELISA | n/a |
GFS:A02310 | uncoupling protein 3 (mitochondrial, proton carrier); Anti | ANTIBODIES | n/a |
GFS:P02310 | uncoupling protein 3 (mitochondrial, proton carrier); Protien | Protien | n/a |