Symbol: Name: ID: |
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) GFS:2309 |
Gene name: | UCP2 |
Chromosome: | 11q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SLC25A8 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109354 | Rat Genome Database ID: | RGD:3932 |
HGNC ID: | HGNC:12518 | RefSeq IDs: | NM_003355 |
Entrez Gene ID: | 7351 | Ensembl Gene ID: | ENSG00000175567 |
VEGA IDs: | UniProt ID: | P55851 | |
UCSC ID: | uc001oup.1 | OMIM ID: | 601693 |
Pubmed: | PMID9196039 | ||
CCDS IDs: | CCDSCCDS8228.1 |
Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Products for UCP2 gene
Catalog | Product Name | Application | Company |
GFS:E02309 | uncoupling protein 2 (mitochondrial, proton carrier); ELISA kit | ELISA | n/a |
GFS:A02309 | uncoupling protein 2 (mitochondrial, proton carrier); Anti | ANTIBODIES | n/a |
GFS:P02309 | uncoupling protein 2 (mitochondrial, proton carrier); Protien | Protien | n/a |