Symbol: Name: ID: |
UHRF1 ubiquitin-like with PHD and ring finger domains 1 GFS:2345 |
Gene name: | UHRF1 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ICBP90, Np95, FLJ21925, RNF106 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338889 | Rat Genome Database ID: | RGD:1595855 |
HGNC ID: | HGNC:12556 | RefSeq IDs: | NM_001048201 |
Entrez Gene ID: | 29128 | Ensembl Gene ID: | ENSG00000034063 |
VEGA IDs: | UniProt ID: | Q96T88 | |
UCSC ID: | uc002mbo.2 | OMIM ID: | 607990 |
Pubmed: | PMID10646863 | ||
CCDS IDs: |
Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene.
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
Products for UHRF1 gene
Catalog | Product Name | Application | Company |
GFS:E02345 | ubiquitin-like with PHD and ring finger domains 1; ELISA kit | ELISA | n/a |
GFS:A02345 | ubiquitin-like with PHD and ring finger domains 1; Anti | ANTIBODIES | n/a |
GFS:P02345 | ubiquitin-like with PHD and ring finger domains 1; Protien | Protien | n/a |