Symbol: Name: ID: |
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) GFS:2306 |
Gene name: | UCHL3 |
Chromosome: | 13q21.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1355274 | Rat Genome Database ID: | RGD:1561196 |
HGNC ID: | HGNC:12515 | RefSeq IDs: | NM_006002 |
Entrez Gene ID: | 7347 | Ensembl Gene ID: | ENSG00000118939 |
VEGA IDs: | OTTHUMG00000017090 | UniProt ID: | P15374 |
UCSC ID: | uc001vjq.2 | OMIM ID: | 603090 |
Pubmed: | PMID2530630 | ||
CCDS IDs: | CCDSCCDS9453.1 |
Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.
Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory.
Products for UCHL3 gene
Catalog | Product Name | Application | Company |
GFS:E02306 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); ELISA kit | ELISA | n/a |
GFS:A02306 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Anti | ANTIBODIES | n/a |
GFS:P02306 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Protien | Protien | n/a |