Symbol: Name: ID: |
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) GFS:2305 |
Gene name: | UCHL1 |
Chromosome: | 4p13 |
Previous Symbols: | PARK5 |
Previous Names: | |
Aliases: | PGP9.5, Uch-L1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103149 | Rat Genome Database ID: | RGD:3928 |
HGNC ID: | HGNC:12513 | RefSeq IDs: | NM_004181 |
Entrez Gene ID: | 7345 | Ensembl Gene ID: | ENSG00000154277 |
VEGA IDs: | OTTHUMG00000099377 | UniProt ID: | P09936 |
UCSC ID: | uc003gvo.2 | OMIM ID: | 191342 |
Pubmed: | PMID1840236 | ||
CCDS IDs: | CCDSCCDS3462.1 |
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Products for UCHL1 gene
Catalog | Product Name | Application | Company |
GFS:E02305 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ELISA kit | ELISA | n/a |
GFS:A02305 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Anti | ANTIBODIES | n/a |
GFS:P02305 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Protien | Protien | n/a |