Symbol: Name: ID: |
TDP2 tyrosyl-DNA phosphodiesterase 2 GFS:6680 |
Gene name: | TDP2 |
Chromosome: | 6p22.3-p22.1 |
Previous Symbols: | TTRAP |
Previous Names: | TRAF and TNF receptor associated protein |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1860486 | Rat Genome Database ID: | RGD:1560342 |
HGNC ID: | HGNC:17768 | RefSeq IDs: | NM_016614 |
Entrez Gene ID: | 51567 | Ensembl Gene ID: | ENSG00000111802 |
VEGA IDs: | OTTHUMG00000014360 | UniProt ID: | O95551 |
UCSC ID: | uc003nej.2 | OMIM ID: | 605764 |
Pubmed: | PMID11478795 | ||
CCDS IDs: | CCDSCCDS4557.1 |
TRAF and TNF receptor-associated protein is a protein that in humans is encoded by the TTRAP gene.
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Products for TDP2 gene
Catalog | Product Name | Application | Company |
GFS:E06680 | tyrosyl-DNA phosphodiesterase 2; ELISA kit | ELISA | n/a |
GFS:A06680 | tyrosyl-DNA phosphodiesterase 2; Anti | ANTIBODIES | n/a |
GFS:P06680 | tyrosyl-DNA phosphodiesterase 2; Protien | Protien | n/a |