Symbol: Name: ID: |
TDP1 tyrosyl-DNA phosphodiesterase 1 GFS:7702 |
Gene name: | TDP1 |
Chromosome: | 14q32.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ11090, SCAN1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920036 | Rat Genome Database ID: | RGD:1309618 |
HGNC ID: | HGNC:18884 | RefSeq IDs: | NM_018319 |
Entrez Gene ID: | 55775 | Ensembl Gene ID: | ENSG00000042088 |
VEGA IDs: | UniProt ID: | Q9NUW8 | |
UCSC ID: | uc001xxz.2 | OMIM ID: | 607198 |
Pubmed: | PMID11839309 PMID 12244316 | ||
CCDS IDs: | CCDSCCDS9888.1 |
Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Products for TDP1 gene
Catalog | Product Name | Application | Company |
GFS:E07702 | tyrosyl-DNA phosphodiesterase 1; ELISA kit | ELISA | n/a |
GFS:A07702 | tyrosyl-DNA phosphodiesterase 1; Anti | ANTIBODIES | n/a |
GFS:P07702 | tyrosyl-DNA phosphodiesterase 1; Protien | Protien | n/a |