Symbol: Name: ID: |
TMOD1 tropomodulin 1 GFS:1687 |
Gene name: | TMOD1 |
Chromosome: | 9q22 |
Previous Symbols: | D9S57E, TMOD |
Previous Names: | |
Aliases: | ETMOD |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98775 | Rat Genome Database ID: | RGD:3874 |
HGNC ID: | HGNC:11871 | RefSeq IDs: | NM_001166116 |
Entrez Gene ID: | 7111 | Ensembl Gene ID: | ENSG00000136842 |
VEGA IDs: | OTTHUMG00000020325 | UniProt ID: | P28289 |
UCSC ID: | uc004axl.1 | OMIM ID: | 190930 |
Pubmed: | PMID1370827 PMID 8661028 | ||
CCDS IDs: | CCDSCCDS6726.1 |
Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene. This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
Products for TMOD1 gene
Catalog | Product Name | Application | Company |
GFS:E01687 | tropomodulin 1; ELISA kit | ELISA | n/a |
GFS:A01687 | tropomodulin 1; Anti | ANTIBODIES | n/a |
GFS:P01687 | tropomodulin 1; Protien | Protien | n/a |