Symbol: Name: ID: |
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) GFS:1633 |
Gene name: | TIMM8B |
Chromosome: | 11q23.1-q23.2 |
Previous Symbols: | |
Previous Names: | translocase of inner mitochondrial membrane 8 (yeast) homolog B |
Aliases: | TIM8B, DDP2, FLJ21744, MGC102866, MGC117373 |
Name Aliases: | mitochondrial import inner membrane translocase subunit Tim8 B |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353424 | Rat Genome Database ID: | RGD:619840 |
HGNC ID: | HGNC:11818 | RefSeq IDs: | NM_012459 |
Entrez Gene ID: | 26521 | Ensembl Gene ID: | ENSG00000150779 |
VEGA IDs: | OTTHUMG00000162261 | UniProt ID: | Q9Y5J9 |
UCSC ID: | uc001pmx.2 | OMIM ID: | 606659 |
Pubmed: | PMID10552927 | ||
CCDS IDs: | CCDSCCDS8357.1 |
The TIMM8B gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Products for TIMM8B gene
Catalog | Product Name | Application | Company |
GFS:E01633 | translocase of inner mitochondrial membrane 8 homolog B (yeast); ELISA kit | ELISA | n/a |
GFS:A01633 | translocase of inner mitochondrial membrane 8 homolog B (yeast); Anti | ANTIBODIES | n/a |
GFS:P01633 | translocase of inner mitochondrial membrane 8 homolog B (yeast); Protien | Protien | n/a |