Symbol: Name: ID: |
TBL1X transducin (beta)-like 1X-linked GFS:1436 |
Gene name: | TBL1X |
Chromosome: | Xp22.3 |
Previous Symbols: | TBL1 |
Previous Names: | transducin (beta)-like 1 |
Aliases: | EBI |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1336172 | Rat Genome Database ID: | RGD:1563868 |
HGNC ID: | HGNC:11585 | RefSeq IDs: | NM_001139466 |
Entrez Gene ID: | 6907 | Ensembl Gene ID: | ENSG00000101849 |
VEGA IDs: | OTTHUMG00000021117 | UniProt ID: | O60907 |
UCSC ID: | uc004csr.2 | OMIM ID: | 300196 |
Pubmed: | PMID10330347 | ||
CCDS IDs: | CCDSCCDS14133.1 CCDS CCDS48078.1 |
Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq].
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Products for TBL1X gene
Catalog | Product Name | Application | Company |
GFS:E01436 | transducin (beta)-like 1X-linked; ELISA kit | ELISA | n/a |
GFS:A01436 | transducin (beta)-like 1X-linked; Anti | ANTIBODIES | n/a |
GFS:P01436 | transducin (beta)-like 1X-linked; Protien | Protien | n/a |