Symbol: Name: ID: |
TCEA2 transcription elongation factor A (SII), 2 GFS:1464 |
Gene name: | TCEA2 |
Chromosome: | 20q13.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TFIIS |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107368 | Rat Genome Database ID: | RGD:61825 |
HGNC ID: | HGNC:11614 | RefSeq IDs: | NM_003195 |
Entrez Gene ID: | 6919 | Ensembl Gene ID: | ENSG00000171703 |
VEGA IDs: | OTTHUMG00000033026 | UniProt ID: | Q15560 |
UCSC ID: | uc011abr.1 | OMIM ID: | 604784 |
Pubmed: | PMID9441762 PMID 8566795 | ||
CCDS IDs: | CCDSCCDS13553.1 CCDS CCDS13554.1 |
Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene. The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Products for TCEA2 gene
Catalog | Product Name | Application | Company |
GFS:E01464 | transcription elongation factor A (SII), 2; ELISA kit | ELISA | n/a |
GFS:A01464 | transcription elongation factor A (SII), 2; Anti | ANTIBODIES | n/a |
GFS:P01464 | transcription elongation factor A (SII), 2; Protien | Protien | n/a |