Symbol: Name: ID: |
TDG thymine-DNA glycosylase GFS:1519 |
Gene name: | TDG |
Chromosome: | 12q24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | G/T mismatch-specific thymine DNA glycosylase |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108247 | Rat Genome Database ID: | RGD:620959 |
HGNC ID: | HGNC:11700 | RefSeq IDs: | NM_003211 |
Entrez Gene ID: | 6996 | Ensembl Gene ID: | ENSG00000139372 |
VEGA IDs: | UniProt ID: | Q13569 | |
UCSC ID: | uc001tkg.2 | OMIM ID: | 601423 |
Pubmed: | PMID8662714 PMID 9299239 | ||
CCDS IDs: | CCDSCCDS9095.1 |
G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Products for TDG gene
Catalog | Product Name | Application | Company |
GFS:E01519 | thymine-DNA glycosylase; ELISA kit | ELISA | n/a |
GFS:A01519 | thymine-DNA glycosylase; Anti | ANTIBODIES | n/a |
GFS:P01519 | thymine-DNA glycosylase; Protien | Protien | n/a |