Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the TDGF1 gene. This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.