Symbol: Name: ID: |
TLN1 talin 1 GFS:1659 |
Gene name: | TLN1 |
Chromosome: | 9p23-p21 |
Previous Symbols: | TLN |
Previous Names: | |
Aliases: | ILWEQ |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1099832 | Rat Genome Database ID: | RGD:1306247 |
HGNC ID: | HGNC:11845 | RefSeq IDs: | NM_006289 |
Entrez Gene ID: | 7094 | Ensembl Gene ID: | ENSG00000137076 |
VEGA IDs: | OTTHUMG00000019874 | UniProt ID: | Q9Y490 |
UCSC ID: | uc003zxt.2 | OMIM ID: | 186745 |
Pubmed: | PMID7635475 PMID 10610730 | ||
CCDS IDs: | CCDSCCDS35009.1 |
Talin-1 is a protein that in humans is encoded by the TLN1 gene. This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Products for TLN1 gene
Catalog | Product Name | Application | Company |
GFS:E01659 | talin 1; ELISA kit | ELISA | n/a |
GFS:A01659 | talin 1; Anti | ANTIBODIES | n/a |
GFS:P01659 | talin 1; Protien | Protien | n/a |