Symbol: Name: ID: |
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 GFS:4788 |
Gene name: | SS18L1 |
Chromosome: | 20q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0693 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444061 | Rat Genome Database ID: | RGD:621847 |
HGNC ID: | HGNC:15592 | RefSeq IDs: | NM_198935 |
Entrez Gene ID: | 26039 | Ensembl Gene ID: | ENSG00000184402 |
VEGA IDs: | OTTHUMG00000032902 | UniProt ID: | O75177 |
UCSC ID: | uc002ycb.2 | OMIM ID: | 606472 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS13491.1 |
SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L1 gene is homologous to SS18.[supplied by OMIM, Jul 2002].
Function: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
Products for SS18L1 gene
Catalog | Product Name | Application | Company |
GFS:E04788 | synovial sarcoma translocation gene on chromosome 18-like 1; ELISA kit | ELISA | n/a |
GFS:A04788 | synovial sarcoma translocation gene on chromosome 18-like 1; Anti | ANTIBODIES | n/a |
GFS:P04788 | synovial sarcoma translocation gene on chromosome 18-like 1; Protien | Protien | n/a |