Symbol: Name: ID: |
SIP1 survival of motor neuron protein interacting protein 1 GFS:792 |
Gene name: | SIP1 |
Chromosome: | 14q21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | GEMIN2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913853 | Rat Genome Database ID: | RGD:620842 |
HGNC ID: | HGNC:10884 | RefSeq IDs: | NM_001009182 |
Entrez Gene ID: | 8487 | Ensembl Gene ID: | ENSG00000092208 |
VEGA IDs: | OTTHUMG00000028816 | UniProt ID: | O14893 |
UCSC ID: | uc001wuq.2 | OMIM ID: | 602595 |
Pubmed: | PMID9323130 PMID 9323129 | ||
CCDS IDs: | CCDSCCDS9669.1 CCDS CCDS32068.1 CCDS CCDS41946.1 |
Survival of motor neuron protein-interacting protein 1 is a protein that in humans is encoded by the SIP1 gene. This gene encodes one of the proteins found in the SMN complex, which consists of the suvival of motor neuron protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq].
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.
Products for SIP1 gene
Catalog | Product Name | Application | Company |
GFS:E00792 | survival of motor neuron protein interacting protein 1; ELISA kit | ELISA | n/a |
GFS:A00792 | survival of motor neuron protein interacting protein 1; Anti | ANTIBODIES | n/a |
GFS:P00792 | survival of motor neuron protein interacting protein 1; Protien | Protien | n/a |