Symbol: Name: ID: |
SOCS6 suppressor of cytokine signaling 6 GFS:5920 |
Gene name: | SOCS6 |
Chromosome: | 18q22 |
Previous Symbols: | SOCS4 |
Previous Names: | suppressor of cytokine signaling 4 |
Aliases: | CIS4, SSI4, HSPC060, STATI4, STAI4, Cish4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1924885 | Rat Genome Database ID: | RGD:1304632 |
HGNC ID: | HGNC:16833 | RefSeq IDs: | NM_004232 |
Entrez Gene ID: | 9306 | Ensembl Gene ID: | ENSG00000170677 |
VEGA IDs: | OTTHUMG00000132816 | UniProt ID: | O14544 |
UCSC ID: | uc002lkr.1 | OMIM ID: | 605118 |
Pubmed: | PMID9344848 PMID 11042152 | ||
CCDS IDs: | CCDSCCDS11998.1 |
Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Products for SOCS6 gene
Catalog | Product Name | Application | Company |
GFS:E05920 | suppressor of cytokine signaling 6; ELISA kit | ELISA | n/a |
GFS:A05920 | suppressor of cytokine signaling 6; Anti | ANTIBODIES | n/a |
GFS:P05920 | suppressor of cytokine signaling 6; Protien | Protien | n/a |