Symbol: Name: ID: |
SOCS5 suppressor of cytokine signaling 5 GFS:5939 |
Gene name: | SOCS5 |
Chromosome: | 2p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0671, SOCS-5, CIS6, CISH6, Cish5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2385459 | Rat Genome Database ID: | RGD:1564914 |
HGNC ID: | HGNC:16852 | RefSeq IDs: | NM_014011 |
Entrez Gene ID: | 9655 | Ensembl Gene ID: | ENSG00000171150 |
VEGA IDs: | OTTHUMG00000128852 | UniProt ID: | O75159 |
UCSC ID: | uc002rvf.2 | OMIM ID: | 607094 |
Pubmed: | PMID9734811 PMID 11230166 | ||
CCDS IDs: | CCDSCCDS1830.1 |
Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008].
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 is involved in regulating T-helper cell differentiation by inhibition of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity). May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Products for SOCS5 gene
Catalog | Product Name | Application | Company |
GFS:E05939 | suppressor of cytokine signaling 5; ELISA kit | ELISA | n/a |
GFS:A05939 | suppressor of cytokine signaling 5; Anti | ANTIBODIES | n/a |
GFS:P05939 | suppressor of cytokine signaling 5; Protien | Protien | n/a |