Symbol: Name: ID: |
SREBF2 sterol regulatory element binding transcription factor 2 GFS:1183 |
Gene name: | SREBF2 |
Chromosome: | 22q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SREBP2, bHLHd2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107585 | Rat Genome Database ID: | RGD:1307751 |
HGNC ID: | HGNC:11290 | RefSeq IDs: | NM_004599 |
Entrez Gene ID: | 6721 | Ensembl Gene ID: | ENSG00000198911 |
VEGA IDs: | OTTHUMG00000151261 | UniProt ID: | Q12772 |
UCSC ID: | uc003bbi.2 | OMIM ID: | 600481 |
Pubmed: | PMID7903453 | ||
CCDS IDs: | CCDSCCDS14023.1 |
Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Products for SREBF2 gene
Catalog | Product Name | Application | Company |
GFS:E01183 | sterol regulatory element binding transcription factor 2; ELISA kit | ELISA | n/a |
GFS:A01183 | sterol regulatory element binding transcription factor 2; Anti | ANTIBODIES | n/a |
GFS:P01183 | sterol regulatory element binding transcription factor 2; Protien | Protien | n/a |