Symbol: Name: ID: |
SREBF1 sterol regulatory element binding transcription factor 1 GFS:1181 |
Gene name: | SREBF1 |
Chromosome: | 17p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SREBP1, bHLHd1, SREBP-1c |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107606 | Rat Genome Database ID: | RGD:69423 |
HGNC ID: | HGNC:11289 | RefSeq IDs: | NM_001005291 |
Entrez Gene ID: | 6720 | Ensembl Gene ID: | ENSG00000072310 |
VEGA IDs: | OTTHUMG00000059313 | UniProt ID: | P36956 |
UCSC ID: | uc002grt.1 | OMIM ID: | 184756 |
Pubmed: | PMID8402897 PMID 7759101 | ||
CCDS IDs: | CCDSCCDS11189.1 CCDS CCDS32583.1 |
Sterol regulatory element-binding protein 1 (SREBP-1) also known as sterol regulatory element-binding transcription factor 1 (SREBF1) is a protein that in humans is encoded by the SREBF1 gene. This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Products for SREBF1 gene
Catalog | Product Name | Application | Company |
GFS:E01181 | sterol regulatory element binding transcription factor 1; ELISA kit | ELISA | n/a |
GFS:A01181 | sterol regulatory element binding transcription factor 1; Anti | ANTIBODIES | n/a |
GFS:P01181 | sterol regulatory element binding transcription factor 1; Protien | Protien | n/a |