Symbol: Name: ID: |
SPHK2 sphingosine kinase 2 GFS:7678 |
Gene name: | SPHK2 |
Chromosome: | 19q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1861380 | Rat Genome Database ID: | RGD:1307757 |
HGNC ID: | HGNC:18859 | RefSeq IDs: | NM_001204158 |
Entrez Gene ID: | 56848 | Ensembl Gene ID: | ENSG00000063176 |
VEGA IDs: | UniProt ID: | Q9NRA0 | |
UCSC ID: | uc002pjr.2 | OMIM ID: | 607092 |
Pubmed: | PMID10751414 PMID 17895250 | ||
CCDS IDs: | CCDSCCDS12727.1 |
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.
Products for SPHK2 gene
Catalog | Product Name | Application | Company |
GFS:E07678 | sphingosine kinase 2; ELISA kit | ELISA | n/a |
GFS:A07678 | sphingosine kinase 2; Anti | ANTIBODIES | n/a |
GFS:P07678 | sphingosine kinase 2; Protien | Protien | n/a |