Symbol: Name: ID: |
SPHK1 sphingosine kinase 1 GFS:1131 |
Gene name: | SPHK1 |
Chromosome: | 17q25.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SPHK |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1316649 | Rat Genome Database ID: | RGD:620048 |
HGNC ID: | HGNC:11240 | RefSeq IDs: | NM_001142601 |
Entrez Gene ID: | 8877 | Ensembl Gene ID: | ENSG00000176170 |
VEGA IDs: | UniProt ID: | Q9NYA1 | |
UCSC ID: | uc002jrj.2 | OMIM ID: | 603730 |
Pubmed: | PMID9726979 | ||
CCDS IDs: | CCDSCCDS11744.1 CCDS CCDS45785.1 |
Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM].
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
Products for SPHK1 gene
Catalog | Product Name | Application | Company |
GFS:E01131 | sphingosine kinase 1; ELISA kit | ELISA | n/a |
GFS:A01131 | sphingosine kinase 1; Anti | ANTIBODIES | n/a |
GFS:P01131 | sphingosine kinase 1; Protien | Protien | n/a |