Symbol: Name: ID: |
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) GFS:1028 |
Gene name: | SMPD2 |
Chromosome: | 6q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | nSMase, ISC1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1278330 | Rat Genome Database ID: | RGD:619753 |
HGNC ID: | HGNC:11121 | RefSeq IDs: | NM_003080 |
Entrez Gene ID: | 6610 | Ensembl Gene ID: | ENSG00000135587 |
VEGA IDs: | OTTHUMG00000015348 | UniProt ID: | O60906 |
UCSC ID: | uc003pti.2 | OMIM ID: | 603498 |
Pubmed: | PMID9520418 | ||
CCDS IDs: | CCDSCCDS5075.1 |
Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene. This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
Products for SMPD2 gene
Catalog | Product Name | Application | Company |
GFS:E01028 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); ELISA kit | ELISA | n/a |
GFS:A01028 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Anti | ANTIBODIES | n/a |
GFS:P01028 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Protien | Protien | n/a |