Symbol: Name: ID: |
SYNE2 spectrin repeat containing, nuclear envelope 2 GFS:6178 |
Gene name: | SYNE2 |
Chromosome: | 14q22.1-q22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SYNE-2, DKFZP434H2235, Nesprin-2, NUANCE, NUA, KIAA1011 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2449316 | Rat Genome Database ID: | RGD:1305248 |
HGNC ID: | HGNC:17084 | RefSeq IDs: | NM_015180 |
Entrez Gene ID: | 23224 | Ensembl Gene ID: | ENSG00000054654 |
VEGA IDs: | OTTHUMG00000140349 | UniProt ID: | Q8WXH0 |
UCSC ID: | uc001xgl.2 | OMIM ID: | 608442 |
Pubmed: | PMID10231032 PMID 10878022 | ||
CCDS IDs: | CCDSCCDS9761.2 CCDS CCDS41963.1 CCDS CCDS45124.1 CCDS CCDS45125.1 |
Nesprin-2 is a protein that in humans is encoded by the SYNE2 gene.
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Function: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.
Products for SYNE2 gene
Catalog | Product Name | Application | Company |
GFS:E06178 | spectrin repeat containing, nuclear envelope 2; ELISA kit | ELISA | n/a |
GFS:A06178 | spectrin repeat containing, nuclear envelope 2; Anti | ANTIBODIES | n/a |
GFS:P06178 | spectrin repeat containing, nuclear envelope 2; Protien | Protien | n/a |