Symbol: Name: ID: |
SYNE1 spectrin repeat containing, nuclear envelope 1 GFS:6183 |
Gene name: | SYNE1 |
Chromosome: | 6q24.2-q25.3 |
Previous Symbols: | C6orf98 |
Previous Names: | chromosome 6 open reading frame 98 |
Aliases: | SYNE-1B, KIAA0796, 8B, nesprin-1, enaptin, MYNE1, CPG2, dJ45H2.2, SCAR8, ARCA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927152 | Rat Genome Database ID: | RGD:620546 |
HGNC ID: | HGNC:17089 | RefSeq IDs: | NM_015293 |
Entrez Gene ID: | 23345 | Ensembl Gene ID: | ENSG00000131018 |
VEGA IDs: | OTTHUMG00000015841 | UniProt ID: | Q8NF91 |
UCSC ID: | uc010kiw.2 | OMIM ID: | 608441 |
Pubmed: | PMID9872452 PMID 10878022 | ||
CCDS IDs: | CCDSCCDS5235.1 CCDS CCDS5236.1 CCDS CCDS5237.1 CCDS CCDS5238.1 |
This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Function: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Required for centrosome migration to the apical cell surface during early ciliogenesis.
Products for SYNE1 gene
Catalog | Product Name | Application | Company |
GFS:E06183 | spectrin repeat containing, nuclear envelope 1; ELISA kit | ELISA | n/a |
GFS:A06183 | spectrin repeat containing, nuclear envelope 1; Anti | ANTIBODIES | n/a |
GFS:P06183 | spectrin repeat containing, nuclear envelope 1; Protien | Protien | n/a |