Symbol: Name: ID: |
SLCO1C1 solute carrier organic anion transporter family, member 1C1 GFS:3295 |
Gene name: | SLCO1C1 |
Chromosome: | 12p12.2 |
Previous Symbols: | SLC21A14 |
Previous Names: | solute carrier family 21 (organic anion transporter), member 14 |
Aliases: | OATP-F, OATP1C1, OATP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889679 | Rat Genome Database ID: | RGD:628660 |
HGNC ID: | HGNC:13819 | RefSeq IDs: | NM_001145944 |
Entrez Gene ID: | 53919 | Ensembl Gene ID: | ENSG00000139155 |
VEGA IDs: | UniProt ID: | Q9NYB5 | |
UCSC ID: | uc001rei.2 | OMIM ID: | 613389 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8683.1 |
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
Function: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).
Products for SLCO1C1 gene
Catalog | Product Name | Application | Company |
GFS:E03295 | solute carrier organic anion transporter family, member 1C1; ELISA kit | ELISA | n/a |
GFS:A03295 | solute carrier organic anion transporter family, member 1C1; Anti | ANTIBODIES | n/a |
GFS:P03295 | solute carrier organic anion transporter family, member 1C1; Protien | Protien | n/a |