Symbol: Name: ID: |
SLCO1B1 solute carrier organic anion transporter family, member 1B1 GFS:865 |
Gene name: | SLCO1B1 |
Chromosome: | 12p12 |
Previous Symbols: | SLC21A6 |
Previous Names: | solute carrier family 21 (organic anion transporter), member 6 |
Aliases: | OATP-C, LST-1, OATP1B1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:10959 | RefSeq IDs: | NM_006446 |
Entrez Gene ID: | 10599 | Ensembl Gene ID: | ENSG00000134538 |
VEGA IDs: | UniProt ID: | Q9Y6L6 | |
UCSC ID: | uc001req.3 | OMIM ID: | 604843 |
Pubmed: | PMID10358072 | ||
CCDS IDs: | CCDSCCDS8685.1 |
Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
Products for SLCO1B1 gene
Catalog | Product Name | Application | Company |
GFS:E00865 | solute carrier organic anion transporter family, member 1B1; ELISA kit | ELISA | n/a |
GFS:A00865 | solute carrier organic anion transporter family, member 1B1; Anti | ANTIBODIES | n/a |
GFS:P00865 | solute carrier organic anion transporter family, member 1B1; Protien | Protien | n/a |