Symbol: Name: ID: |
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 GFS:5130 |
Gene name: | SERPINA3 |
Chromosome: | 14q32.1 |
Previous Symbols: | AACT |
Previous Names: | alpha-1-antichymotrypsin, "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3" |
Aliases: | ACT, alpha-1-antichymotrypsin |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105045 | Rat Genome Database ID: | RGD:3747 |
HGNC ID: | HGNC:16 | RefSeq IDs: | NM_001085 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000196136 | |
VEGA IDs: | OTTHUMG00000029851 | UniProt ID: | P01011 |
UCSC ID: | uc001ydp.2 | OMIM ID: | 107280 |
Pubmed: | PMID3260956 | ||
CCDS IDs: | CCDSCCDS32150.1 |
Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serpin superfamily
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Products for SERPINA3 gene
Catalog | Product Name | Application | Company |
GFS:E05130 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; ELISA kit | ELISA | n/a |
GFS:A05130 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Anti | ANTIBODIES | n/a |
GFS:P05130 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Protien | Protien | n/a |