Symbol: Name: ID: |
SCG5 secretogranin V (7B2 protein) GFS:730 |
Gene name: | SCG5 |
Chromosome: | 15q13-q14 |
Previous Symbols: | SGNE1 |
Previous Names: | secretory granule, neuroendocrine protein 1 (7B2 protein) |
Aliases: | 7B2, SgV |
Name Aliases: | prohormone convertase chaperone |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98289 | Rat Genome Database ID: | RGD:3669 |
HGNC ID: | HGNC:10816 | RefSeq IDs: | NM_001144757 |
Entrez Gene ID: | 6447 | Ensembl Gene ID: | ENSG00000166922 |
VEGA IDs: | OTTHUMG00000159447 | UniProt ID: | P05408 |
UCSC ID: | uc001zha.2 | OMIM ID: | 173120 |
Pubmed: | PMID8162254 PMID 12646671 | ||
CCDS IDs: | CCDSCCDS45207.1 CCDS CCDS45208.1 |
Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene. The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 and is required for the production of an active PC2 enzyme.
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Products for SCG5 gene
Catalog | Product Name | Application | Company |
GFS:E00730 | secretogranin V (7B2 protein); ELISA kit | ELISA | n/a |
GFS:A00730 | secretogranin V (7B2 protein); Anti | ANTIBODIES | n/a |
GFS:P00730 | secretogranin V (7B2 protein); Protien | Protien | n/a |