Symbol: Name: ID: |
SOST sclerostin GFS:3267 |
Gene name: | SOST |
Chromosome: | 17q12-q21 |
Previous Symbols: | |
Previous Names: | sclerosteosis |
Aliases: | VBCH |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921749 | Rat Genome Database ID: | RGD:69358 |
HGNC ID: | HGNC:13771 | RefSeq IDs: | NM_025237 |
Entrez Gene ID: | 50964 | Ensembl Gene ID: | ENSG00000167941 |
VEGA IDs: | UniProt ID: | Q9BQB4 | |
UCSC ID: | uc002iec.1 | OMIM ID: | 605740 |
Pubmed: | PMID11179006 PMID 11181578 | ||
CCDS IDs: | CCDSCCDS11468.1 |
Sclerostin is a protein that in humans is encoded by the SOST gene.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Negative regulator of bone growth.
Products for SOST gene
Catalog | Product Name | Application | Company |
GFS:E03267 | sclerostin; ELISA kit | ELISA | n/a |
GFS:A03267 | sclerostin; Anti | ANTIBODIES | n/a |
GFS:P03267 | sclerostin; Protien | Protien | n/a |