Symbol: Name: ID: |
RRM2B ribonucleotide reductase M2 B (TP53 inducible) GFS:6380 |
Gene name: | RRM2B |
Chromosome: | 8q23.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | p53R2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2155865 | Rat Genome Database ID: | RGD:1306045 |
HGNC ID: | HGNC:17296 | RefSeq IDs: | NM_001172477 |
Entrez Gene ID: | 50484 | Ensembl Gene ID: | ENSG00000048392 |
VEGA IDs: | UniProt ID: | Q7LG56 | |
UCSC ID: | uc003ykn.2 | OMIM ID: | 604712 |
Pubmed: | PMID10716435 PMID 10980602 PMID 17486094 | ||
CCDS IDs: | CCDSCCDS34932.1 |
Ribonucleoside-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene.
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
Function: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Products for RRM2B gene
Catalog | Product Name | Application | Company |
GFS:E06380 | ribonucleotide reductase M2 B (TP53 inducible); ELISA kit | ELISA | n/a |
GFS:A06380 | ribonucleotide reductase M2 B (TP53 inducible); Anti | ANTIBODIES | n/a |
GFS:P06380 | ribonucleotide reductase M2 B (TP53 inducible); Protien | Protien | n/a |