Symbol: Name: ID: |
PRMT6 protein arginine methyltransferase 6 GFS:7114 |
Gene name: | PRMT6 |
Chromosome: | 1p13.2 |
Previous Symbols: | HRMT1L6 |
Previous Names: | HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae) |
Aliases: | FLJ10559 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2139971 | Rat Genome Database ID: | RGD:1304701 |
HGNC ID: | HGNC:18241 | RefSeq IDs: | NM_018137 |
Entrez Gene ID: | 55170 | Ensembl Gene ID: | ENSG00000198890 |
VEGA IDs: | OTTHUMG00000010964 | UniProt ID: | Q96LA8 |
UCSC ID: | uc010ous.1 | OMIM ID: | 608274 |
Pubmed: | PMID11724789 | ||
CCDS IDs: | CCDSCCDS41360.1 |
Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for PRMT6 gene
Catalog | Product Name | Application | Company |
GFS:E07114 | protein arginine methyltransferase 6; ELISA kit | ELISA | n/a |
GFS:A07114 | protein arginine methyltransferase 6; Anti | ANTIBODIES | n/a |
GFS:P07114 | protein arginine methyltransferase 6; Protien | Protien | n/a |