Symbol: Name: ID: |
PRMT5 protein arginine methyltransferase 5 GFS:801 |
Gene name: | PRMT5 |
Chromosome: | 14q11.2 |
Previous Symbols: | HRMT1L5, SKB1 |
Previous Names: | skb1 (S. pombe) homolog, "SKB1 homolog (S. pombe)" |
Aliases: | SKB1Hs |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1351645 | Rat Genome Database ID: | RGD:1309053 |
HGNC ID: | HGNC:10894 | RefSeq IDs: | NM_001039619 |
Entrez Gene ID: | 10419 | Ensembl Gene ID: | ENSG00000100462 |
VEGA IDs: | OTTHUMG00000028709 | UniProt ID: | O14744 |
UCSC ID: | uc001whm.1 | OMIM ID: | 604045 |
Pubmed: | PMID9843966 | ||
CCDS IDs: | CCDSCCDS9579.1 CCDS CCDS41922.1 |
Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene. Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.
Products for PRMT5 gene
Catalog | Product Name | Application | Company |
GFS:E00801 | protein arginine methyltransferase 5; ELISA kit | ELISA | n/a |
GFS:A00801 | protein arginine methyltransferase 5; Anti | ANTIBODIES | n/a |
GFS:P00801 | protein arginine methyltransferase 5; Protien | Protien | n/a |