Symbol: Name: ID: |
PROK1 prokineticin 1 GFS:7304 |
Gene name: | PROK1 |
Chromosome: | 1p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PK1, PRK1, EGVEGF |
Name Aliases: | black mamba toxin-related protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2180370 | Rat Genome Database ID: | RGD:620898 |
HGNC ID: | HGNC:18454 | RefSeq IDs: | NM_032414 |
Entrez Gene ID: | 84432 | Ensembl Gene ID: | ENSG00000143125 |
VEGA IDs: | OTTHUMG00000011569 | UniProt ID: | P58294 |
UCSC ID: | uc001dzs.2 | OMIM ID: | 606233 |
Pubmed: | PMID11259612 | ||
CCDS IDs: | CCDSCCDS825.1 |
The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011].
Function: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
Products for PROK1 gene
Catalog | Product Name | Application | Company |
GFS:E07304 | prokineticin 1; ELISA kit | ELISA | n/a |
GFS:A07304 | prokineticin 1; Anti | ANTIBODIES | n/a |
GFS:P07304 | prokineticin 1; Protien | Protien | n/a |