Symbol: Name: ID: |
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa GFS:716 |
Gene name: | POLR3D |
Chromosome: | 8q21 |
Previous Symbols: | BN51T |
Previous Names: | BN51 (BHK21) temperature sensitivity complementing |
Aliases: | TSBN51, RPC4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914315 | Rat Genome Database ID: | RGD:1311816 |
HGNC ID: | HGNC:1080 | RefSeq IDs: | NM_001722 |
Entrez Gene ID: | 661 | Ensembl Gene ID: | ENSG00000168495 |
VEGA IDs: | UniProt ID: | P05423 | |
UCSC ID: | uc003xbl.2 | OMIM ID: | 187280 |
Pubmed: | PMID12391170 PMID 11279001 | ||
CCDS IDs: | CCDSCCDS34858.1 |
DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene. This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq].
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity)
Products for POLR3D gene
Catalog | Product Name | Application | Company |
GFS:E00716 | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; ELISA kit | ELISA | n/a |
GFS:A00716 | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; Anti | ANTIBODIES | n/a |
GFS:P00716 | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; Protien | Protien | n/a |