Symbol: Name: ID: |
POLR1A polymerase (RNA) I polypeptide A, 194kDa GFS:6345 |
Gene name: | POLR1A |
Chromosome: | 2p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DKFZP586M0122, FLJ21915, RPO1-4, RPA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1096397 | Rat Genome Database ID: | RGD:620824 |
HGNC ID: | HGNC:17264 | RefSeq IDs: | NM_015425 |
Entrez Gene ID: | 25885 | Ensembl Gene ID: | ENSG00000068654 |
VEGA IDs: | OTTHUMG00000153165 | UniProt ID: | O95602 |
UCSC ID: | uc002sqs.2 | OMIM ID: | |
Pubmed: | PMID9236775 | ||
CCDS IDs: | CCDSCCDS42706.1 |
DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene.
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
Products for POLR1A gene
Catalog | Product Name | Application | Company |
GFS:E06345 | polymerase (RNA) I polypeptide A, 194kDa; ELISA kit | ELISA | n/a |
GFS:A06345 | polymerase (RNA) I polypeptide A, 194kDa; Anti | ANTIBODIES | n/a |
GFS:P06345 | polymerase (RNA) I polypeptide A, 194kDa; Protien | Protien | n/a |