Symbol: Name: ID: |
PEG10 paternally expressed 10 GFS:3440 |
Gene name: | PEG10 |
Chromosome: | 7q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1051, HB-1, MEF3L, RGAG3, Mar2, Mart2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2157785 | Rat Genome Database ID: | |
HGNC ID: | HGNC:14005 | RefSeq IDs: | NM_001040152 |
Entrez Gene ID: | 23089 | Ensembl Gene ID: | ENSG00000242265 |
VEGA IDs: | OTTHUMG00000155578 | UniProt ID: | Q86TG7 |
UCSC ID: | uc003uno.2 | OMIM ID: | 609810 |
Pubmed: | PMID11318613 PMID 15716091 PMID 16093683 | ||
CCDS IDs: |
Retrotransposon-derived protein PEG10 is a protein that in humans is encoded by the PEG10 gene.
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq].
Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).
Products for PEG10 gene
Catalog | Product Name | Application | Company |
GFS:E03440 | paternally expressed 10; ELISA kit | ELISA | n/a |
GFS:A03440 | paternally expressed 10; Anti | ANTIBODIES | n/a |
GFS:P03440 | paternally expressed 10; Protien | Protien | n/a |