SPEG complex locus, also known as SPEG, is a human gene.

This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010].
Function: Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.