Symbol: Name: ID: |
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) GFS:5074 |
Gene name: | PARD6A |
Chromosome: | 16q22.1-q22.3 |
Previous Symbols: | |
Previous Names: | par-6 (partitioning defective 6, C.elegans) homolog alpha |
Aliases: | PAR-6, PAR-6A, TAX40, PAR6alpha, TIP-40 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927223 | Rat Genome Database ID: | RGD:1303273 |
HGNC ID: | HGNC:15943 | RefSeq IDs: | NM_001037281 |
Entrez Gene ID: | 50855 | Ensembl Gene ID: | ENSG00000102981 |
VEGA IDs: | OTTHUMG00000137534 | UniProt ID: | Q9NPB6 |
UCSC ID: | uc002ett.2 | OMIM ID: | 607484 |
Pubmed: | PMID9482110 PMID 11260256 | ||
CCDS IDs: | CCDSCCDS10843.1 CCDS CCDS45514.1 |
Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Products for PARD6A gene
Catalog | Product Name | Application | Company |
GFS:E05074 | par-6 partitioning defective 6 homolog alpha (C. elegans); ELISA kit | ELISA | n/a |
GFS:A05074 | par-6 partitioning defective 6 homolog alpha (C. elegans); Anti | ANTIBODIES | n/a |
GFS:P05074 | par-6 partitioning defective 6 homolog alpha (C. elegans); Protien | Protien | n/a |