Symbol: Name: ID: |
PARD3 par-3 partitioning defective 3 homolog (C. elegans) GFS:5179 |
Gene name: | PARD3 |
Chromosome: | 10p11.22 |
Previous Symbols: | |
Previous Names: | par-3 (partitioning defective 3, C.elegans) homolog |
Aliases: | PAR3, PARD3A, Bazooka, Baz, ASIP |
Name Aliases: | atypical PKC isotype-specific interacting protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2135608 | Rat Genome Database ID: | RGD:620374 |
HGNC ID: | HGNC:16051 | RefSeq IDs: | NM_001184785 |
Entrez Gene ID: | 56288 | Ensembl Gene ID: | ENSG00000148498 |
VEGA IDs: | OTTHUMG00000017948 | UniProt ID: | Q8TEW0 |
UCSC ID: | uc010qej.1 | OMIM ID: | 606745 |
Pubmed: | PMID10934474 | ||
CCDS IDs: | CCDSCCDS7178.1 |
Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM, Jul 2002].
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.
Products for PARD3 gene
Catalog | Product Name | Application | Company |
GFS:E05179 | par-3 partitioning defective 3 homolog (C. elegans); ELISA kit | ELISA | n/a |
GFS:A05179 | par-3 partitioning defective 3 homolog (C. elegans); Anti | ANTIBODIES | n/a |
GFS:P05179 | par-3 partitioning defective 3 homolog (C. elegans); Protien | Protien | n/a |