Symbol: Name: ID: |
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 GFS:3333 |
Gene name: | NUDT21 |
Chromosome: | 16q12.2 |
Previous Symbols: | CPSF5 |
Previous Names: | cleavage and polyadenylation specific factor 5, 25 kDa, "cleavage and polyadenylation specific factor 5, 25 kD subunit" |
Aliases: | CFIM25 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915469 | Rat Genome Database ID: | RGD:1305766 |
HGNC ID: | HGNC:13870 | RefSeq IDs: | NM_007006 |
Entrez Gene ID: | 11051 | Ensembl Gene ID: | ENSG00000167005 |
VEGA IDs: | OTTHUMG00000133240 | UniProt ID: | O43809 |
UCSC ID: | uc002eja.2 | OMIM ID: | 604978 |
Pubmed: | PMID9659921 | ||
CCDS IDs: | CCDSCCDS10760.1 |
Cleavage and polyadenylation specificity factor subunit 5 is a protein that in humans is encoded by the NUDT21 gene.
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Products for NUDT21 gene
Catalog | Product Name | Application | Company |
GFS:E03333 | nudix (nucleoside diphosphate linked moiety X)-type motif 21; ELISA kit | ELISA | n/a |
GFS:A03333 | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Anti | ANTIBODIES | n/a |
GFS:P03333 | nudix (nucleoside diphosphate linked moiety X)-type motif 21; Protien | Protien | n/a |