Symbol: Name: ID: |
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein GFS:5946 |
Gene name: | NOS1AP |
Chromosome: | 1q23.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0464, CAPON |
Name Aliases: | C-terminal PDZ domain ligand of neuronal nitric oxide synthase |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917979 | Rat Genome Database ID: | RGD:620106 |
HGNC ID: | HGNC:16859 | RefSeq IDs: | NM_001126060 |
Entrez Gene ID: | 9722 | Ensembl Gene ID: | ENSG00000198929 |
VEGA IDs: | OTTHUMG00000024049 | UniProt ID: | O75052 |
UCSC ID: | uc001gbv.2 | OMIM ID: | 605551 |
Pubmed: | PMID9455484 PMID 9459447 | ||
CCDS IDs: | CCDSCCDS1237.1 CCDS CCDS44267.1 |
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein is an enzyme that in humans is encoded by the NOS1AP gene.
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009].
Function: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).
Products for NOS1AP gene
Catalog | Product Name | Application | Company |
GFS:E05946 | nitric oxide synthase 1 (neuronal) adaptor protein; ELISA kit | ELISA | n/a |
GFS:A05946 | nitric oxide synthase 1 (neuronal) adaptor protein; Anti | ANTIBODIES | n/a |
GFS:P05946 | nitric oxide synthase 1 (neuronal) adaptor protein; Protien | Protien | n/a |