Symbol: Name: ID: |
MYCNOS v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand GFS:5997 |
Gene name: | MYCNOS |
Chromosome: | 2p24.1 |
Previous Symbols: | |
Previous Names: | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), opposite strand |
Aliases: | NCYM |
Name Aliases: | DNA binding transcriptional activator |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:16911 | RefSeq IDs: | NR_026766 |
Entrez Gene ID: | 10408 | Ensembl Gene ID: | ENSG00000233718 |
VEGA IDs: | OTTHUMG00000151741 | UniProt ID: | P40205 |
UCSC ID: | uc002rch.1 | OMIM ID: | 605374 |
Pubmed: | PMID1419902 PMID 12880964 | ||
CCDS IDs: |
The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis. [provided by RefSeq, Jul 2008].
Function: May have a functional role during normal fetal development.
Products for MYCNOS gene
Catalog | Product Name | Application | Company |
GFS:E05997 | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand; ELISA kit | ELISA | n/a |
GFS:A05997 | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand; Anti | ANTIBODIES | n/a |
GFS:P05997 | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand; Protien | Protien | n/a |