Symbol: Name: ID: |
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 GFS:5873 |
Gene name: | NMNAT2 |
Chromosome: | 1q25 |
Previous Symbols: | C1orf15 |
Previous Names: | chromosome 1 open reading frame 15 |
Aliases: | KIAA0479, PNAT2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444155 | Rat Genome Database ID: | RGD:1307331 |
HGNC ID: | HGNC:16789 | RefSeq IDs: | NM_015039 |
Entrez Gene ID: | 23057 | Ensembl Gene ID: | ENSG00000157064 |
VEGA IDs: | OTTHUMG00000035519 | UniProt ID: | Q9BZQ4 |
UCSC ID: | uc001gqc.1 | OMIM ID: | 608701 |
Pubmed: | PMID11318611 PMID 12359228 | ||
CCDS IDs: | CCDSCCDS1353.1 CCDS CCDS1354.1 |
Nicotinamide mononucleotide adenylyltransferase 2 is an enzyme that in humans is encoded by the NMNAT2 gene.
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannnot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).
Products for NMNAT2 gene
Catalog | Product Name | Application | Company |
GFS:E05873 | nicotinamide nucleotide adenylyltransferase 2; ELISA kit | ELISA | n/a |
GFS:A05873 | nicotinamide nucleotide adenylyltransferase 2; Anti | ANTIBODIES | n/a |
GFS:P05873 | nicotinamide nucleotide adenylyltransferase 2; Protien | Protien | n/a |