Symbol: Name: ID: |
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 GFS:6778 |
Gene name: | NMNAT1 |
Chromosome: | 1p36.22 |
Previous Symbols: | |
Previous Names: | nicotinamide nucleotide adenylyltransferase |
Aliases: | NMNAT, PNAT1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913704 | Rat Genome Database ID: | RGD:1310996 |
HGNC ID: | HGNC:17877 | RefSeq IDs: | NM_022787 |
Entrez Gene ID: | 64802 | Ensembl Gene ID: | ENSG00000173614 |
VEGA IDs: | OTTHUMG00000001799 | UniProt ID: | Q9HAN9 |
UCSC ID: | uc001aqp.2 | OMIM ID: | 608700 |
Pubmed: | PMID11248244 PMID 11027696 | ||
CCDS IDs: | CCDSCCDS108.1 |
Nicotinamide mononucleotide adenylyltransferase 1 is an enzyme that in humans is encoded by the NMNAT1 gene.
The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Products for NMNAT1 gene
Catalog | Product Name | Application | Company |
GFS:E06778 | nicotinamide nucleotide adenylyltransferase 1; ELISA kit | ELISA | n/a |
GFS:A06778 | nicotinamide nucleotide adenylyltransferase 1; Anti | ANTIBODIES | n/a |
GFS:P06778 | nicotinamide nucleotide adenylyltransferase 1; Protien | Protien | n/a |