Symbol: Name: ID: |
NEIL2 nei endonuclease VIII-like 2 (E. coli) GFS:7769 |
Gene name: | NEIL2 |
Chromosome: | 8p23.1 |
Previous Symbols: | |
Previous Names: | nei like 2 (E. coli) |
Aliases: | NEH2, FLJ31644, MGC2832, MGC4505 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2686058 | Rat Genome Database ID: | RGD:1312033 |
HGNC ID: | HGNC:18956 | RefSeq IDs: | NM_001135746 |
Entrez Gene ID: | 252969 | Ensembl Gene ID: | ENSG00000154328 |
VEGA IDs: | OTTHUMG00000090753 | UniProt ID: | Q969S2 |
UCSC ID: | uc003wue.2 | OMIM ID: | 608933 |
Pubmed: | PMID12097317 PMID 17686777 | ||
CCDS IDs: | CCDSCCDS5984.1 CCDS CCDS47802.1 CCDS CCDS47803.1 |
Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008].
Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Products for NEIL2 gene
Catalog | Product Name | Application | Company |
GFS:E07769 | nei endonuclease VIII-like 2 (E. coli); ELISA kit | ELISA | n/a |
GFS:A07769 | nei endonuclease VIII-like 2 (E. coli); Anti | ANTIBODIES | n/a |
GFS:P07769 | nei endonuclease VIII-like 2 (E. coli); Protien | Protien | n/a |