Symbol: Name: ID: |
NEIL1 nei endonuclease VIII-like 1 (E. coli) GFS:7297 |
Gene name: | NEIL1 |
Chromosome: | 15q33.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ22402, hFPG1, NEI1, FPG1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920024 | Rat Genome Database ID: | RGD:1306077 |
HGNC ID: | HGNC:18448 | RefSeq IDs: | NM_024608 |
Entrez Gene ID: | 79661 | Ensembl Gene ID: | ENSG00000140398 |
VEGA IDs: | OTTHUMG00000142821 | UniProt ID: | Q96FI4 |
UCSC ID: | uc002bad.2 | OMIM ID: | 608844 |
Pubmed: | PMID11904416 | ||
CCDS IDs: | CCDSCCDS10278.1 |
Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
Products for NEIL1 gene
Catalog | Product Name | Application | Company |
GFS:E07297 | nei endonuclease VIII-like 1 (E. coli); ELISA kit | ELISA | n/a |
GFS:A07297 | nei endonuclease VIII-like 1 (E. coli); Anti | ANTIBODIES | n/a |
GFS:P07297 | nei endonuclease VIII-like 1 (E. coli); Protien | Protien | n/a |