Symbol: Name: ID: |
MMP25 matrix metallopeptidase 25 GFS:3611 |
Gene name: | MMP25 |
Chromosome: | 16p13.3 |
Previous Symbols: | MMPL1, MMP20 |
Previous Names: | matrix metalloproteinase 25, "matrix metallopeptidase-like 1" |
Aliases: | MT6-MMP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2443938 | Rat Genome Database ID: | |
HGNC ID: | HGNC:14246 | RefSeq IDs: | NM_022468 |
Entrez Gene ID: | 64386 | Ensembl Gene ID: | ENSG00000008516 |
VEGA IDs: | UniProt ID: | Q9NPA2 | |
UCSC ID: | uc002cth.2 | OMIM ID: | 608482 |
Pubmed: | PMID10628838 PMID 10706098 | ||
CCDS IDs: | CCDSCCDS10492.1 |
Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May activate progelatinase A.
Products for MMP25 gene
Catalog | Product Name | Application | Company |
GFS:E03611 | matrix metallopeptidase 25; ELISA kit | ELISA | n/a |
GFS:A03611 | matrix metallopeptidase 25; Anti | ANTIBODIES | n/a |
GFS:P03611 | matrix metallopeptidase 25; Protien | Protien | n/a |