Symbol: Name: ID: |
LY96 lymphocyte antigen 96 GFS:6243 |
Gene name: | LY96 |
Chromosome: | 8q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MD-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341909 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17156 | RefSeq IDs: | NM_001195797 |
Entrez Gene ID: | 23643 | Ensembl Gene ID: | ENSG00000154589 |
VEGA IDs: | UniProt ID: | Q9Y6Y9 | |
UCSC ID: | uc003yad.2 | OMIM ID: | 605243 |
Pubmed: | PMID10359581 PMID 11466383 | ||
CCDS IDs: | CCDSCCDS6216.1 |
Lymphocyte antigen 96 is a protein that in humans is encoded by the LY96 gene.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010].
Function: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
Products for LY96 gene
Catalog | Product Name | Application | Company |
GFS:E06243 | lymphocyte antigen 96; ELISA kit | ELISA | n/a |
GFS:A06243 | lymphocyte antigen 96; Anti | ANTIBODIES | n/a |
GFS:P06243 | lymphocyte antigen 96; Protien | Protien | n/a |