Symbol: Name: ID: |
ACLY ATP citrate lyase GFS:1360 |
Gene name: | ACLY |
Chromosome: | 17q21.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ATPCL, CLATP, ACL |
Name Aliases: | ATP citrate synthase |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103251 | Rat Genome Database ID: | RGD:2018 |
HGNC ID: | HGNC:115 | RefSeq IDs: | NM_001096 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000131473 | |
VEGA IDs: | OTTHUMG00000133507 | UniProt ID: | P53396 |
UCSC ID: | uc002hyg.2 | OMIM ID: | 108728 |
Pubmed: | PMID1371749 PMID 8088842 | ||
CCDS IDs: | CCDSCCDS11412.1 CCDS CCDS11413.1 |
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Products for ACLY gene
Catalog | Product Name | Application | Company |
GFS:E01360 | ATP citrate lyase; ELISA kit | ELISA | n/a |
GFS:A01360 | ATP citrate lyase; Anti | ANTIBODIES | n/a |
GFS:P01360 | ATP citrate lyase; Protien | Protien | n/a |